I. Control of Atropisomerism en Route to the Michellamines. II. Aqueous Suzuki-Miyaura Couplings at Ambient Temperatures. III. Studies in Asymmetric Copper Hydride Chemistry

I. Control of Atropisomerism en Route to the Michellamines. II. Aqueous Suzuki-Miyaura Couplings at Ambient Temperatures. III. Studies in Asymmetric Copper Hydride Chemistry

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With current focus on the environment, research into the minimization of chemical waste is increasing. Organic solvents has been identified as the major contributor to chemical waste from the chemical industry, and many efforts have been made to replace these with water. Moreover, performing organic reactions in water facilitate the isolation of products. It is here described how use of dilute aqueous solutions of nonionic surfactants allows efficient Suzuki-Miyaura cross-couplings of arylboronic acids with a wide array of aryl halides and pseudohalides, including sterically hindered and lipophilic substrates, in most cases at room temperature.Table 7: Suzuki-Miyaura reactions of aryl chloridesa#39;1 Pd cat., Et, N Ar1B(OH)2 + Ar2Cl x equiv PTS (y%)/H20 Arx-Ar2 entry x Ar1 ... o k k * k k 3 1 24 20 24 50 k 6 1 11 20 50 85 82 99 28 red nd 97 98 100 100 100 90 100 100 nd nd nd mediate anbsp;...


Title:I. Control of Atropisomerism en Route to the Michellamines. II. Aqueous Suzuki-Miyaura Couplings at Ambient Temperatures. III. Studies in Asymmetric Copper Hydride Chemistry
Author:Tue Bruun Petersen
Publisher:ProQuest - 2008
ISBN-13:

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