Probabalistic Methods for Interpreting Electron-density Maps

Probabalistic Methods for Interpreting Electron-density Maps

4.11 - 1251 ratings - Source

With recent advances in structural genomics, there has been considerable interest in the rapid determination of protein structures in a high-throughput setting. One bottleneck in this process arises in protein crystallography, and deals with interpretation of the electron-density map, the three-dimensional qpictureq of the protein that crystallography produces. This thesis presents a novel solution to this important problem of electron-density map interpretation. I apply probabilistic methods to automate the interpretation of poor-quality electron-density maps.Alternatively, one could use a fixed-size sphere to align a template to the map, then compute the correlation coefficient over ... I first show the error introduced by band-limiting density templates, then I compare several different first-pass filters.

Title:Probabalistic Methods for Interpreting Electron-density Maps
Author:Frank Paul DiMaio
Publisher:ProQuest - 2008


You Must CONTINUE and create a free account to access unlimited downloads & streaming