These results suggest that, like purified CVF, HC3 causes a downstream signaling and recruitment of the complement convertase component C3/C5, which results in complement depletion and myocardial protection following MI/R. Demonstration of the efficacy of HC3 in mice to preserve cardiac function suggests it may have the potential to be used as a therapeutic in the prevention of human MI/R injuries.Schematic of complement activation with the injection of cobra venom factor (CVF ) and complement activation without CVF. Cobra venom factor causes the continued hydrolysis of C3/C5, while in the absence of CVF, C3/C5 is inactivated anbsp;...
|Title||:||The Immunological Role of Recombinant Humanized Cobra Venom Factor in Mediating Myocardial Ischemia-reperfusion Injuries|
|Author||:||William Brian Gorsuch|
|Publisher||:||ProQuest - 2008|