The Immunological Role of Recombinant Humanized Cobra Venom Factor in Mediating Myocardial Ischemia-reperfusion Injuries

The Immunological Role of Recombinant Humanized Cobra Venom Factor in Mediating Myocardial Ischemia-reperfusion Injuries

4.11 - 1251 ratings - Source

These results suggest that, like purified CVF, HC3 causes a downstream signaling and recruitment of the complement convertase component C3/C5, which results in complement depletion and myocardial protection following MI/R. Demonstration of the efficacy of HC3 in mice to preserve cardiac function suggests it may have the potential to be used as a therapeutic in the prevention of human MI/R injuries.Schematic of complement activation with the injection of cobra venom factor (CVF ) and complement activation without CVF. Cobra venom factor causes the continued hydrolysis of C3/C5, while in the absence of CVF, C3/C5 is inactivated anbsp;...


Title:The Immunological Role of Recombinant Humanized Cobra Venom Factor in Mediating Myocardial Ischemia-reperfusion Injuries
Author:William Brian Gorsuch
Publisher:ProQuest - 2008
ISBN-13:

Continue

You Must CONTINUE and create a free account to access unlimited downloads & streaming